Drivers beware: Avoid Interstate 25 south of downtown Denver this weekend.

The Colorado Department of Transportation (CDOT) is shutting down I-25 between Santa Fe Drive and U.S. 6 for much of the weekend. The details from CDOT:

The highway will initially close Friday, Aug. 8, at 10 p.m. and remain closed until 8 a.m. Saturday. The roadway will remain open throughout the day on Saturday. Then, Saturday night at 10 p.m., both directions of I-25 will close again, reopening by 5 a.m. Monday. Crews will begin setting closures approximately one hour prior to the full closures being implemented.

“Realistically, the best bet is to cross I-25 off the list for that weekend and use alternative modes of transportation or alternate routes,” CDOT project director Kevin Sullivan says in a statement.

CDOT recommends the following detours, marked in green on the map above:

Northbound I-25 will detour to northbound Santa Fe Drive, continue north to 8th Avenue, west on 8th Avenue to Kalamath Street, and south on Kalamath Street to westbound US 6 to reconnect with northbound I-25.

Southbound I-25 will detour west on US 6 to Federal Boulevard, south on Federal Boulevard to 5th Avenue to merge onto eastbound US 6, and east on US 6 to reconnect with southbound I-25. There could also be delays along eastbound US 6 near I-25 with additional traffic following this detour route.

Northbound Santa Fe Drive: In conjunction with this closure, northbound Santa Fe Drive will close just south of I-25 over the weekend, with traffic detoured on Mississippi Avenue to northbound Broadway and eventually Lincoln Street. Access to businesses along Santa Fe Drive will be available via Alameda Avenue. Detour signage will guide commuters through the area.

The work will result in a fourth lane on northbound I-25 between Santa Fe Drive and U.S. 6. That will open to the public on Monday at 5 a.m.

Visit CDOT's website for information about all of this weekend's road closures in the Denver metro area.