The move will leave it to U.S. attorneys where pot is legal to decide whether to aggressively enforce federal marijuana law.
Here are some of the more notable laws that will go into effect Monday, after winning passage during the 2017 legislative session.
Kriho, an activist for hemp and marijuana legalization, may be better known for encouraging a jury to ignore a law they didn't agree with.
A lack of clarity has led to speculation that masses of people experiencing homelessness have moved to Denver solely to get stoned.
The proposal has the backing of the La Alma Lincoln Park Neighborhood Association, which submitted a letter of support to the city.
The American Veterinary Medical Association wants the DEA to declassify marijuana as a Schedule 1 drug "to facilitate research opportunities."
Data from the Colorado State Patrol show that marijuana DUIs dropped 33 percent so far this year compared to the same time last year.
Keep your eyes out for a Dodge Sprinter van around Boulder. What looks like a nondescript cargo van is actually a cutting-edge marijuana research lab.
Voters go to the polls next Tuesday to consider issues facing Colorado's cities and counties.