When state voters legalized recreational marijuana through Amendment 64 earlier this decade, the e-cigarette industry had just started to take off.
Colorado is becoming an epicenter in the fight over teen vaping.
The new rules would also tighten regulations on online sales.
A 2017 Colorado survey observed a disconnect in how young people see vaping and e-cigarettes and the health risks.
A CDC finding that 25 percent of high schoolers vape coincides with a push in several mountain towns to raise the age for tobacco and nicotine purchases.
A new study also says that Colorado leads 37 states surveyed for use of electronic cigarettes among high school students.
The director of the state health department says e-cigarette companies are marketing to teens and putting them at risk.
Public health officials worry that teen use of e-cigarettes could be an emerging disaster, reversing years of declines in smoking.
"The idea of taking money that's from the tobacco industry is just antithetical to everything we do," said Karen Emmons of Harvard's public health school.